To minimize the potential of overdosage or the development of dependence, limit the prescribing and dispensing of sedative-hypnotic barbiturates, to the amount required to the interval until the next appointment
pentobarbital will lessen the level or impact of midostaurin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Steer clear of or Use Alternate Drug. Powerful CYP3A4 inducers might decrease midostaurin concentrations resulting in lowered efficacy.
pentobarbital will reduce the level or outcome of solifenacin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Monitor.
pentobarbital will decrease the level or impact of fludrocortisone by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Watch.
pentobarbital will decrease the extent or result of losartan by affecting hepatic enzyme CYP2C9/ten metabolism. Small/Significance Not known.
Check Intently (1)pentobarbital will reduce the extent or impact of osilodrostat by affecting hepatic/intestinal enzyme CYP3A4 metabolism.
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pentobarbital will reduce the extent or impact of osilodrostat by influencing hepatic/intestinal enzyme CYP3A4 metabolism.
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pentobarbital will minimize the extent or outcome of bosentan by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Insignificant/Importance Not known.
pentobarbital will lower the level or effect of estradiol vaginal by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep an eye on.
pentobarbital will lower the level or result of buprenorphine, very long-performing injection by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Observe Intently. Patients who transfer to buprenorphine long-acting injection from transmucosal buprenorphine coadministered with CYP3A4 inducers really should be monitored to ensure buprenorphine plasma amounts are adequate.
[three] It can also be utilised for brief-time period therapy of insomnia but has become mainly replaced with the benzodiazepine relatives of drugs.
Contraindicated (1)pentobarbital will decrease the extent or influence of cobimetinib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Steer clear of coadministration. Strong or average CYP3A inducers may well lessen cobimetinib systemic exposure by >eighty% and lessen its efficacy.